Quantification of Myocardial Blood Flow Using Microbubbles
نویسندگان
چکیده
Ultrasound can cause microbubble destruction. We hypothesized that ultrasound induced microbubble destruction can be used to quantify myocardial blood flow. in viva experiments were performed where microbubbles were delivered as a constant infusion, and ultrasound examination was performed using different pulsing intervals from which microbubble velocity and microvascular cross-sectional area were calculated. The product of the two represents myocardial blood flow. Excellent correlations were found between ultrasound-derived flow and independent parameters of flow. This novel approach has the potential for measuring tissue perhtsion in any organ accessible to ultrasound.
منابع مشابه
Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion.
BACKGROUND Ultrasound can cause microbubble destruction. If microbubbles are administered as a continuous infusion, then their destruction within the myocardium and measurement of their myocardial reappearance rate at steady state will provide a measure of mean myocardial microbubble velocity. Conversely, measurement of their myocardial concentration at steady state will provide an assessment o...
متن کاملBasis for detection of stenosis using venous administration of microbubbles during myocardial contrast echocardiography: bolus or continuous infusion?
OBJECTIVES This study sought to determine the basis of detection of stenosis by myocardial contrast echocardiography using venous administration of microbubbles and to define the relative merits of bolus injection versus continuous infusion. BACKGROUND The degree of video intensity (VI) disparity in myocardial beds supplied by stenosed and normal coronary arteries can be used to quantify sten...
متن کاملIn vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography. Comparison with radiolabeled red blood cells.
Myocardial contrast echocardiography (MCE) is a new technique for assessing myocardial perfusion that uses intracoronary injections of microbubbles of air. Because these microbubbles have a mean diameter of 4.3 +/- 0.3 microns and an intravascular rheology similar to that of red blood cells (RBCs), we hypothesized that their mean myocardial transit rates recorded on echocardiography would provi...
متن کاملAssessment of myocardial perfusion abnormalities with contrast-enhanced two-dimensional echocardiography.
clinical and pathologic aspects of coronary artery disease in men of various age groups: a study of 950 autopsied cases from the Armed Forces Institute of Pathology. evaluation of left ventricular thrombi by two-dimensional echocar-diography: effect of anticoagulant therapy. SUMMARY A new echocardiographic contrast agent, gelatin-encapsulated microbubbles, that produces an intramyocardial contr...
متن کاملReal-time measurement of renal blood flow in healthy subjects using contrast-enhanced ultrasound.
Current methods for measuring renal blood flow (RBF) are time consuming and not widely available. Contrast-enhanced ultrasound (CEU) is a safe and noninvasive imaging technique suitable for assessment of tissue blood flow, which has been used clinically to assess myocardial blood flow. We tested the utility of CEU in monitoring changes in RBF in healthy volunteers. We utilized CEU to monitor th...
متن کامل